Background: Based on the Basic Health Research in 2018, the prevalence of pregnant women at risk of nutritional deficiencies in Indonesia is 17.3%. According to the Ministry of Health in 2020, out of 4,656,382 pregnant women from all provinces in Indonesia, 451,350 pregnant women were identified as at risk of nutritional deficiencies. Therefore, the percentage of pregnant women experiencing underweight in 2020 was 9.7%. Underweight conditions in pregnant women can lead to disturbances in fetal growth and development, a reduction in nutrient supply to the fetus posing a risk of low birth weight, and additionally blood flow to the fetus decrease leading tp reduced oxygenation which can cause tissue damage and trigger inflammatory reactions. Docosahexanoic Acid is an omega-3 fatty acid whose demand is high during pregnancy, essential not only for the development and growth od the fetus but also crucial for the mother. The administration of DHA supplementation is expected to improve the underweight condition and reduce the impacts resulting from this condition, especially the levels od inflammation in pregnant women.

Method: This study focuses on investigating the mediator correlation of inflammation, specifically IL-6 as a proinflammatory cytokine, with DHA supplementation for 2 months in underweight pregnant women. The research was conducted using a one group pre and post-test experimental design, involving 21 underweight pregnant women samples from Made Community Health Center in Surabaya. Result: Body weight (P = 0.000); Height (P = 0.929); BMI (P = 0.000); MUAC (P = 0.003); Systolic BP (P = 0.108); Diastolic BP (P = 0.631); Fundal height (P = 0.001); IL-6 (P = 0.008).

Conclusion: In this study, a correlation was found between DHA supplementation and the body weight, BMI, MUAC, Fundal height, and IL-6 in underweight pregnant women.