International Journal of
Medical and Pharmaceutical
Research

 Why us?


 Open Access
 Peer-reviewed
 Rapid publication
 Lifetime hosting
 Free indexing service
 Free promotion service
 More citations
 Search engine friendly
Comparative Oral Duloxetine, Melatonin And Tapentadol For Post Spinal Analgesia And Sedation In Knee Arthroscopic Surgeries
Kaneez Fatema, A.K.M Fakhrul Alam, Md. Nazmul Ahsan, Md. Mahbub Ur Rahman, Md. Shafiqul Islam
DOI : 10.5281/zenodo.7747772
Download PDF
Abstract

Background: Arthroscopic knee surgeries are very common procedures as ambulatory day case surgeries and are preferred by most patients. Many patients complain of moderate to severe pain 24 h after surgery and pain affects the patient’s activity level and satisfaction. Post-operative pain is a frequent observation in patients undergoing knee arthroscopic surgeries and remains a challenge to anaesthesiologist. Objective: To assess the efficacy of preoperative duloxetine, melatonin and tapentadol for post spinal analgesia and sedation in knee arthroscopic surgeries. Methods: This prospective, randomized study was conducted at Anesthesia Department, Rahat Anwar Hospital, Band Road, Chandmari, Barishal, Bangladesh from June-2021 to December 2022. After Institutional Ethical Committee clearance and written informed consent in 106 American Society of Anesthesiologists (ASA) I and II patients of either sex between 18-60 years of age, posted for knee arthroscopic surgery under spinal anesthesia. Patients undergoing knee arthroscopic surgery requiring spinal anaesthesia were allocated randomly to four groups of oral Placebo Group A, 20 mg Duloxetine Group B, 3 mg Melatonin Group C, 100 mg Tapentadol Group D, 90 minutes before surgery. We assessed block characteristics, intraoperative sedation using Ramsay sedation scores, postoperative pain scores using Numeric Rating Score, time to use of first analgesic, 24-hours analgesic consumption, additional analgesic consumption and any adverse effects. Results: Total 106 patients Spinal anaesthesia was successfully performed. No significant difference in age, sex, weight and duration of surgery were found among the groups. Time to first post-operative analgesic request (477.96±97.85 min) and total diclofenac consumption (111.25±50.78mg) was significantly longer in Group D compared to Group A. Although post-operative pain assessed by NRS (numerical rating scale) was significantly lower in Group D as compared to Group A, B and C at 2 hours after surgery, no significant difference was observed at any time point among groups. Mean duration of post-operative analgesia was 477.96±97.85 minutes in Tapentodol Group (p value<0.001). Total 24 hours diclofenac consumption is minimum in Tapentodol Group (p 0.04). No statistical significant differences were present in the onset of the spinal block and Ramsay Sedation Score among the Groups. Conclusion: Preoperative administration of oral tapentadol provides prolonged analgesia with reduced 24-hours analgesic consumption.

Follow Us


About Us


IJMPR is an international open access source for a high quality and peer reviewed journal in the fields of Medical and Pharmaceutical Sciences. IJMPR publishes research papers across all academic disciplines in the fields of Medical, Pharmaceutical Sciences.

Contact Us


editor@ijmpr.in
Copyright © 2023 | IJMPR | All Rights Reserved

Versicherungsvergleich

A PHP Error was encountered

Severity: Notice

Message: fwrite(): write of 34 bytes failed with errno=122 Disk quota exceeded

Filename: drivers/Session_files_driver.php

Line Number: 267

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/cpanel/php/sessions/ea-php74)

Filename: Unknown

Line Number: 0

Backtrace: