Introduction: Inguinal hernia is a common problem and its repair is one of the most commonly performed procedures in general surgical practice. Several methods have been developed including Lichtenstein’s repair. Among these Lichtenstein’s repair has been the standard technique for the last few decades. In recent times a new procedure “no mesh Desarda hernia repair” has emerged as a recognized operative method for inguinal hernia repair. Aim of the study: The aim of the study was to find out the efficacy and safety profile between Desarda and Mesh Hernioplasty (Lichtenstein) in Inguinal Hermia. Methods: A comparative study between the 50 patients undergoing open mesh and Desarda repair was done based on randomization. All patients were diagnosed with an inguinal hernia from January 2019 to December 2020 at Khulna Medical College and Hospital, Khulna, Bangladesh and some private hospital, Khulna, Bangladesh. Result: During follow up, 5 (20.00%) patients suffered from chronic pain in lictenstein group compared to 3(12.00%) patients in desarda, Recurrence was 4(20.00%) seen in lictenstein group compared to 1 (4.00%) patients in desarda. Seroma was seen in 1 patients in desarda and nil in L group whereas hematoma was seen more in L group. Conclusion: The results of the study showed that the effectiveness of the Desarda technique with respect to influencing the early clinical outcomes of hernia repair is similar to that of the Lichtenstein method. However, the operator in this study showed that the Desarda repair requires significantly shorter operative time, is painless, and less Hospital stays with cost-effectiveness.