Purpose: To find the proportion of dry eye disease and it’s impact on quality of life among postmenopausal women attending ophthalmology outpatient department of tertiary care center in Alappuzha. Materials and methods: In this study, 98 post menopausal women as per inclusion and exclusion criteria were asked to fill OSDI questionnaire composed of 12 items referring to activities in the week prior to completion. Three subscales in it include ocular symptoms, vision related functions and environmental triggers. Each item of the OSDI questionnaire was graded on a score of 0-4.0-indicates none of the time, 1- some of the time, 2 - half of the time, 3 - most of the time, 4- all the time. This score is assessed on a scale of 0-100 Higher scores represents higher disability and symptoms Results: Mean age was found to be 63.2 years with a standard deviation of 6.9 and mean age of menopause was 49.9 years with a standard deviation of 1.3. Proportion of dry eye based on Schirmer test was found to be 67.3%, by TBUT test was 68.4% and by Oxford grading 68.4%. By oxford grading proportion of postmenopausal women with minimal dry eye was 60.2% and with mild dry eye was 8.2%. By OSDI score, 92.4% postmenopausal women with dry eye by Schirmer test were severely affected by dry eye, 89.6% of them with dry eye by TBUT were severely affected. Among persons without dry eye by Schirmer test, 56.3% had normal quality of life, 34.4% had mild to moderate deterioration in quality of life and 9.4% had severe deterioration in quality of life. By TBUT test 58.1% of those without dry eye had normal quality of life, 29% had mild to moderate deterioration in quality of life and 12.9% had severe deterioration in quality of life. By Oxford grading, among persons without dry eye ,58.1% had normal quality of life, 29% had mild to moderate deterioration in quality of life and 12.9 % had severe deterioration in quality of life. 78.57% had gritty eyes, 77.55% had blurred vision, 75.51% had painful eyes, 68.36% had poor vision and 47.95% had sensitivity to light. 70.2% of study participants with postmenopausal period more than 10 years has severe deterioration in quality of life compared to 58.5% in those with postmenopausal period less than or equal to 10 years. Conclusion: Proportion of dry eye was found to be high in postmenopausal women and leads to severe deterioration of their quality of life. Alteration of sex hormones lead to abnormal tear film, which in turn leads to increased symptoms of dry eye. So there is a need to identify dry eye disease in postmenopausal women to maintain ocular surface health and regular ophthalmologic evaluation need to be done.