Introduction:This study aims to determine the role of USG and MDCT with pathological correlation in evaluation of focal hepatic lesions in arriving at a specific diagnosis before surgery.Material and Methods:A total number of 30 patients with liver lesions who were referred to Department of Radiodiagnosis, SSIMS & RC, Davanagere.Results:Correlation of ultrasound diagnosis with histopathology.The sensitivity of diagnosing cholangiocarcinoma is 50%, abscess is 85.71 and HCC is 80%. Whereas for FNH, Metastasis and hydatid cyst it was 100%. The specificity for all the focal hepatic lesions mentioned was 100% except for metastasis which was 77.7%.Correlation of CT diagnosis with histopathology: The sensitivity of diagnosing abscess is 71.42%. Whereas for all other FLL it was 100%. The specificity for all the focal hepatic lesions mentioned was 100% except for metastasis which was 94.4%, HCC was 96%.Conclusion: Contrast enhanced computed tomography with ultrasonography and histopathological correlation is a sensitive tool for diagnosing focal hepatic lesions and differentiating between benign and malignant lesions with high accuracy