Introduction: The process of laryngoscopy and endotracheal tube intubation causes immense sympathetic system activation which further causes intra-operative complications. In high risk patients, this pressor response can increase morbidity and mortality. Dexmedetomidine has good bioavailability and rapid absorption through nasal mucosa so this study evaluates effects of nebulised dexmedetomidine in blunting haemodynamic response to laryngoscopy and intubation. Material and methods: Analytical study was conducted in 100 ASA 1&2 patients. Study population was divided randomly into 2 groups. Control group B(n=50)received nebulisation with 5ml of normal saline and Study group A(n=50)received 1mics/kg dexmedetomidine in 5ml saline 10min before induction in sitting position. Results: Demographics are compared. Following laryngoscopy and intubation SBP, DBP, MAP, HR showed significant increase in control group B as compared to study group A. There was a dose sparing effect of propofol in group A. Conclusion: Nebulised dexmedetomidine effectively blunts the stress response to laryngoscopy and intubation with no adverse effects.