Oxazole is a significant heterocyclic nucleus possessing a wide spectrum of biological activities, which drew the attention of researchers around the globe to synthesize various oxazole derivatives and screen them for their various biological activities. Due to binding with an extensive spectrum of receptors and enzymes easily in biological systems through various non-covalent interactions. Oxazole based compounds as a type of important heterocyclic core, which have been of interest to scientists all over the world, prompting them to synthesize diversified oxazole derivatives.