Background: This study aimed to investigate factors that may impact survival in patients exposed to organophosphorus compound, including route of exposure, presence of certain symptoms , duration of ICU stay and mechanical ventilation. Understanding these factors can help inform treatment decisions and improve patient outcomes. Methods: A retrospective study was conducted on patients who presented to our hospital between 2021 and 2022 with exposure to organophosphorus compound. Data on demographics, route of exposure, and symptoms were collected and analyzed. Survival rates were calculated and compared across different subgroups. Results: Of the 120 patients included in the study, the overall mortality rate was 9%. Males had a higher survival rate than females (92% vs. 85%). Patients who inhaled the compound had a higher survival rate (100%) than those who ingested it (96%). Patients with diarrhea had a 100% survival rate, while those with bronchial secretion had an 18% survival rate. Fasciculations were not found to be a significant predictor of mortality. Conclusion: Our study provides insight into the factors that may impact survival in patients exposed to organophosphorus compound. More research is needed to fully understand the complex interplay of factors that contribute to mortality in these cases.